Drug General Information
Drug ID	D0D2PL
Former ID	DNC005103
Drug Name	8-Methoxy-quinolin-2-ylamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533482]
Structure		Download 2D MOL 3D MOL
Formula	C10H10N2O
Canonical SMILES	COC1=CC=CC2=C1N=C(C=C2)N
InChI	1S/C10H10N2O/c1-13-8-4-2-3-7-5-6-9(11)12-10(7)8/h2-6H,1H3,(H2,11,12)
InChIKey	PMXFKGCLUAFLMH-UHFFFAOYSA-N
PubChem Compound ID	22266820
Target and Pathway
Target(s)	5-hydroxytryptamine 1D receptor	Target Info	Inhibitor	[533482]
	5-hydroxytryptamine 1A receptor	Target Info	Inhibitor	[533482]
	Melanin-concentrating hormone receptor 1	Target Info	Inhibitor	[527194]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapsehsa04024:cAMP signaling pathway
	Serotonergic synapsehsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
	G alpha (q) signalling events
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR downstream signaling
References
Ref 533482	J Med Chem. 1986 Nov;29(11):2375-80.5-HT1 and 5-HT2 binding characteristics of some quipazine analogues.
Ref 527194	Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7.Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1.
Ref 533482	J Med Chem. 1986 Nov;29(11):2375-80.5-HT1 and 5-HT2 binding characteristics of some quipazine analogues.

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