Drug Information

Drug General Information
Drug ID
D0D3PZ
Former ID
DIB019758
Drug Name
dipropyl-5-CT
Synonyms
DP-5-CT; DP5CT; N,N-dipropylcarboxamidotryptamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538731]
Structure
Download
2D MOL
Formula
C17H25N3O
InChI
InChI=1S/C17H25N3O/c1-3-8-20(9-4-2)10-7-14-12-19-16-6-5-13(17(18)21)11-15(14)16/h5-6,11-12,19H,3-4,7-10H2,1-2H3,(H2,18,21)
InChIKey
DPXOFRGRKPFZOD-UHFFFAOYSA-N
PubChem Compound ID
156314
PubChem Substance ID
10252872, 11111033, 15467773, 26755673, 46232141, 47350433, 47425374, 47574448, 47574449, 47796120, 48020066, 48095614, 50111034, 51017598, 57348262, 85209642, 85787317, 90340592, 104443505, 124749691, 124879818, 124879819, 127770003, 131342363, 134223554, 135112296, 135650195, 179235777, 234353577, 242145455
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Agonist [527380]
5-hydroxytryptamine 1F receptor Target Info Agonist [534001]
5-hydroxytryptamine 1D receptor Target Info Agonist [527380]
5-hydroxytryptamine 7 receptor Target Info Agonist [534463]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapsehsa04014:Ras signaling pathway
Calcium signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCRs, Other
References
Ref 538731(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 122).
Ref 527380Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3630-4.
Ref 534001Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):408-12.
Ref 534463Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b). Br J Pharmacol. 1997 Sep;122(1):126-32.

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