Drug Information

Drug General Information
Drug ID
D0D4ZM
Former ID
DIB008572
Drug Name
ISRAPAFANT
Synonyms
Y-24180; Israpafant < Prop INN >; Pafnol (Mitsubishi Pharma, JP); Rac-4-(2-Chlorophenyl)-2-[2-(4-isobutylphenyl)ethyl]-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 3 [539166], [544953]
Structure
Download
2D MOL

3D MOL
Formula
C28H29ClN4S
InChI
InChI=1S/C28H29ClN4S/c1-17(2)15-21-11-9-20(10-12-21)13-14-22-16-24-26(23-7-5-6-8-25(23)29)30-18(3)27-32-31-19(4)33(27)28(24)34-22/h5-12,16-18H,13-15H2,1-4H3
InChIKey
RMSWMRJVUJSDGN-UHFFFAOYSA-N
CAS Number
CAS 117279-73-9
PubChem Compound ID
119175
PubChem Substance ID
10238375, 12014269, 14835129, 29300115, 48413447, 50068867, 50867899, 57339359, 85209698, 104407702, 124894214, 126434265, 129151667, 135075732, 135651337, 137267564, 137619481, 144206851, 160682168, 179149654, 224902424, 226493023, 252215614
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [530579], [531635]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 539166(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1857).
Ref 544953Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001699)
Ref 530579Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor. J Biol Chem. 2010 Feb 19;285(8):5931-40.
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.

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