Drug Information

Drug General Information
Drug ID
D0D6ZB
Former ID
DIB002472
Drug Name
AX-9657
Synonyms
AX-9657; Neutrophil elastase inhibitors (lung disease); HNE inhibitors (lung disease), Kyorin; Neutrophil elastase inhibitors (lung disease), Kyorin
Drug Type
Small molecular drug
Indication Pulmonary disease [ICD9: 460-519; ICD10:J00-J99] Investigative [543602]
Company
Kyorin Pharmaceutical Co Ltd
Structure
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2D MOL

3D MOL
Formula
C22H26N4O3
Canonical SMILES
[C@@H]1(N(C)C)CN(c2c(c3nc4cc(cc(c4c(=O)o3)CC)OC)cccn2)C<br />C1
PubChem Compound ID
25205741
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [543602]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 543602(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2358).
Ref 543602(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2358).

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