Drug Information

Drug General Information
Drug ID
D0D8VE
Former ID
DAP000692
Drug Name
Halothane
Synonyms
Alotano; Anestan; Bromchlortrifluoraethanum; Bromochlorotrifluoroethane; Chalothane; Fluktan; Fluorotane; Fluothane; Ftorotan; Ftuorotan; Halan; Halotan; Halotano; Halothan; Halothanum; Halsan; Narcotan; Narcotane; Narkotan; Phthorothanum; Rhodialothan; Alotano [DCIT]; Ftorotan [Russian]; CF3CHClBr; Freon 123B1; Fluothane (TN); Halotano [INN-Spanish]; Halothane [Anaesthetics, volatile]; Halothanum [INN-Latin]; Narcotann NE-spofa [Russian]; Narcotann ne-spofa; Halothane [INN:BAN:JAN]; Halothane (JP15/USP/INN); (+-)-2-Bromo-2-chloro-1,1,1-trifluoroethane; 1,1,1-Trifluoro-2-bromo-2-chloroethane; 1,1,1-Trifluoro-2-chloro-2-bromoethane; 1-Bromo-1-chloro-2,2,2-trifluoroethane; 2,2,2-Trifluoro-1-chloro-1-bromoethane; 2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE; 2-Brom-2-chlor-1,1,1-trifluorethan
Drug Type
Small molecular drug
Indication Anesthesia [ICD9: 338; ICD10:R20.0] Approved [537886], [539530]
Therapeutic Class
Anesthetics
Structure
Download
2D MOL

3D MOL
Formula
C2HBrClF3
InChI
InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H
InChIKey
BCQZXOMGPXTTIC-UHFFFAOYSA-N
CAS Number
CAS 151-67-7
PubChem Compound ID
3562
PubChem Substance ID
9718, 428040, 3159200, 5123763, 7847608, 7979527, 8145848, 8152252, 10508848, 15067445, 17388981, 24850204, 24891772, 29222693, 46506589, 48423484, 48425179, 49855046, 53790292, 56311498, 56311785, 56311842, 56311861, 56313444, 56313445, 56313447, 57321872, 76126220, 92308210, 103242558, 104006665, 104303878, 114917783, 124890113, 124890114, 125539176, 126677461, 127269303, 127269304, 127269305, 127269306, 127269307, 127269308, 127269309, 127269310, 127269311, 127269312, 127269313, 127269314, 127269315
ChEBI ID
ChEBI:5615
SuperDrug ATC ID
N01AB01
SuperDrug CAS ID
cas=000151677
Target and Pathway
Target(s) Glutamate receptor AMPA subtype Target Info Antagonist [536495]
References
Ref 537886Benzodiazepine utilisation in Australia: report from a new pharmacoepidemiological database. Aust J Public Health. 1993 Dec;17(4):345-9.
Ref 539530(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2401).
Ref 536495Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1. Br J Pharmacol. 2007 Nov;152(6):939-45. Epub 2007 Sep 10.

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