Drug Information

Drug General Information
Drug ID
D0DH1H
Former ID
DIB015527
Drug Name
CCT-241533
Synonyms
CCT-241533; Chk2 inhibitors (cancer); Chk2 inhibitors (cancer), Cancer Research Technology
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [542942]
Company
Cancer Research Technology Ltd
Structure
Download
2D MOL

3D MOL
Formula
C23H27FN4O4
InChI
InChI=1S/C23H27FN4O4/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29/h5-9,15,17,25-26,30H,10-11H2,1-4H3,(H,27,28)/b22-14-/t15-,17-/m1/s1
InChIKey
IXTQNANZDPZION-GSOOIIRJSA-N
PubChem Compound ID
49867844
PubChem Substance ID
136340361, 152258592, 160647427, 223258898, 249565724, 252672023
Target and Pathway
Target(s) Serine/threonine-protein kinase Chk2 Target Info Inhibitor [525351]
KEGG Pathway Cell cycle
p53 signaling pathway
HTLV-I infection
Pathway Interaction Database ATM pathway
FOXM1 transcription factor network
p53 pathway
PLK3 signaling events
Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
WikiPathways DNA Damage Response
ATM Signaling Pathway
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell Cycle
miRNA Regulation of DNA Damage Response
References
Ref 542942(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8044).
Ref 525351CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors. Cancer Res. 2011 Jan 15;71(2):463-72.

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