Drug Information

Drug General Information
Drug ID
D0DP8I
Former ID
DNC000492
Drug Name
Cyclazosin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468080]
Structure
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2D MOL

3D MOL
Formula
C23H27N5O4
InChI
InChI=1S/C23H27N5O4/c1-30-19-12-14-15(13-20(19)31-2)25-23(26-21(14)24)28-10-9-27(16-6-3-4-7-17(16)28)22(29)18-8-5-11-32-18/h5,8,11-13,16-17H,3-4,6-7,9-10H2,1-2H3,(H2,24,25,26)/t16-,17+/m0/s1
InChIKey
XBRXTUGRUXGBPX-DLBZAZTESA-N
CAS Number
CAS 139953-73-4
PubChem Compound ID
132266
PubChem Substance ID
10243077, 15878166, 29310452, 50200412, 57344082, 92098500, 103194742, 104377056, 134339904, 135088820, 135610537, 135650146, 163352673
Target and Pathway
Target(s) Alpha-1B adrenergic receptor Target Info Antagonist [536955]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
AMPK Signaling
References
Ref 468080(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 486).
Ref 536955Identification of alpha1-adrenoceptor subtypes involved in contraction of young CD rat epididymal vas deferens. Eur J Pharmacol. 2009 Jan 14;602(2-3):388-94. Epub 2008 Nov 14.

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