Drug Information

Drug General Information
Drug ID
D0DY5G
Former ID
DIB020903
Drug Name
SB 221284
Synonyms
SB-221284; SB221284
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539210]
Structure
Download
2D MOL
Formula
C16H14F3N3OS
InChI
InChI=1S/C16H14F3N3OS/c1-24-14-7-10-4-6-22(13(10)8-12(14)16(17,18)19)15(23)21-11-3-2-5-20-9-11/h2-3,5,7-9H,4,6H2,1H3,(H,21,23)
InChIKey
OQZOXHCRSXYSPM-UHFFFAOYSA-N
PubChem Compound ID
443389
PubChem Substance ID
13906, 4910702, 10299303, 11114053, 14754355, 24724604, 29215039, 36886716, 51747596, 57404368, 85209599, 85787606, 91722300, 103176795, 103956181, 104629867, 128849265, 135650990, 135698234, 162022818, 162247322, 163123996, 164759717, 179294264, 184565830, 196393056, 202559424, 204360505, 206247055, 223440903, 223468627, 233943817, 241182378, 241375394, 252366105
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Antagonist [527178]
5-hydroxytryptamine 2A receptor Target Info Antagonist [527178]
5-hydroxytryptamine 2B receptor Target Info Antagonist [527178]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 539210(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 191).
Ref 527178Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. Epub 2004 Jul 30.

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