Drug Information

Drug General Information
Drug ID
D0E0WQ
Former ID
DAP001350
Drug Name
Barbital
Synonyms
Barbitale; Barbitalum; Barbitone; Barbitonum; DEBA; Diemal; Diemalum; Diethylbarbitone; Diethylmalonylurea; Dormileno; Dormonal; Ethylbarbital; Hypnogene; Malonal; Medinal; Sedeval; Uronal; Veroletten; Verolettin; Veronal; Vesperal; Barbital Faes Brand; Barbitale [DCIT]; Diethylbarbituric acid; Faes Brand of Barbital; Barbital (TN); Barbital (VAN); Barbital [INN:JAN]; Barbitalum [INN-Latin]; Veronal (TN); Barbital (JP15/INN); Kyselina 5,5-diethylbarbiturova; Kyselina 5,5-diethylbarbiturova [Czech]; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-diethyl-(9CI); 5,5-Diethyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5,5-Diethylbarbituric acid; 5,5-diethyl-1,3-diazinane-2,4,6-trione; 5,5-diethylpyrimidine-2,4,6(1H,3H,5H)-trione; 7979P
Drug Type
Small molecular drug
Indication Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10:F51.0, G47.0] Approved [536555]
Therapeutic Class
Hypnotics and Sedatives
Company
Schering-Plough
Structure
Download
2D MOL

3D MOL
Formula
C8H12N2O3
Canonical SMILES
CCC1(C(=O)NC(=O)NC1=O)CC
InChI
1S/C8H12N2O3/c1-3-8(4-2)5(11)9-7(13)10-6(8)12/h3-4H2,1-2H3,(H2,9,10,11,12,13)
InChIKey
FTOAOBMCPZCFFF-UHFFFAOYSA-N
CAS Number
CAS 57-44-3
PubChem Compound ID
2294
PubChem Substance ID
90340, 589068, 841531, 5611996, 5972305, 7848803, 8151540, 10527896, 11533956, 15219736, 24859202, 24891513, 29215357, 29215358, 29221466, 46508979, 47365376, 48334676, 48415603, 49874104, 50176612, 56459416, 57321239, 57648640, 58694180, 103165760, 104300174, 118189912, 124892181, 125332012, 125736552, 126677738, 127897641, 134338564, 134970868, 137003152, 137204186, 139051997, 144076045, 144205203, 152042447, 160964740, 163120017, 164836116, 164836117, 165319864, 170465829, 175265443, 175442207, 175611463
ChEBI ID
ChEBI:31252
SuperDrug ATC ID
N05CA04
SuperDrug CAS ID
cas=000057443
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Antagonist [536555], [537688]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 536555DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29.
Ref 536555DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29.
Ref 537688Effect of barbiturates on polyphosphoinositide biosynthesis and protein kinase C activity in synaptosomes. Neuropharmacology. 1989 Dec;28(12):1317-23.

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