Drug Information

Drug General Information
Drug ID
D0E2WF
Former ID
DCL000910
Drug Name
ORG 34517/34850
Drug Type
Small molecular drug
Indication Severe mood disorders [ICD9: 296; ICD10:F30-F39] Phase 2 [536580]
Company
Organon
Structure
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2D MOL

3D MOL
Formula
C11H14N6
Canonical SMILES
C1CC(=NN=C(N)N)C2=C1C(=CC=C2)C(=N)N
InChI
1S/C11H14N6/c12-10(13)8-3-1-2-7-6(8)4-5-9(7)16-17-11(14)15/h1-3H,4-5H2,(H3,12,13)(H4,14,15,17)/b16-9+
InChIKey
CYPGNVSXMAUSJY-CXUHLZMHSA-N
PubChem Compound ID
9576789
PubChem Substance ID
7886566, 14749331, 24693748, 26684373, 44714787, 50064476, 50875593, 57373026, 103263058, 103975582, 134339360, 134340478, 135079900, 141857937, 160847746, 162111928, 163394979, 163692549, 163839640, 163843758, 170558735, 172858506, 189659030, 204419641, 223579456, 252499837
Target and Pathway
Target(s) Glucocorticoid receptor Target Info Antagonist [536580]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor network
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Nuclear Receptors Meta-Pathway
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear Receptors
References
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.

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