Drug Information

Drug General Information
Drug ID
D0E4HZ
Former ID
DIB011967
Drug Name
F-12682
Synonyms
Antidepressant, Pierre Fabre; F-12318; 5-HT1B antagonists, Pierre Fabre
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Terminated [546890]
Company
Pierre Fabre SA
Structure
Download
2D MOL

3D MOL
Canonical SMILES
C(=O)(N1CCN(CC1)CCc1ccccc1)Nc1cc(N2CCN(CC2)C)c(cc1)OC
CAS Number
CAS 194942-63-7
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Antagonist [546891], [551730]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 546890Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010898)
Ref 546891Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010898)
Ref 551730Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75.

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