Drug Information

Drug General Information
Drug ID
D0E6DI
Former ID
DCL000239
Drug Name
T487
Synonyms
AC1MVK5U; 2-(2,4-diethyloctoxy)-N-[2-(2,4-diethyloctoxy)ethyl]-N-methyl-ethanamine; 2-(2,4-diethyloctoxy)-N-[2-(2,4-diethyloctoxy)ethyl]-N-methylethanamine
Drug Type
Small molecular drug
Indication Psoriatic disorder [ICD9: 696; ICD10:L40] Discontinued in Phase 2 [549897]
Inflammatory disorder Discontinued in Phase 1 [549897]
Company
Amgen
Structure
Download
2D MOL

3D MOL
Formula
C29H61NO2
Canonical SMILES
CCCCC(CC)CC(CC)COCCN(C)CCOCC(CC)CC(CC)CCCC
InChI
1S/C29H61NO2/c1-8-14-16-26(10-3)22-28(12-5)24-31-20-18-30(7)19-21-32-25-29(13-6)23-27(11-4)17-15-9-2/h26-29H,8-25H2,1-7H3
InChIKey
SBJNERILXQKELG-UHFFFAOYSA-N
PubChem Compound ID
3684533
PubChem Substance ID
5052931, 9837042, 40206767, 78832781, 112123632, 118232380, 126271170, 229786785, 241340362, 243887767
Target and Pathway
Target(s) C-X-C chemokine receptor type 3 Target Info Antagonist [536005], [536059]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database CXCR3-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 549897Clinical pipeline report, company report or official report of ChemoCentryx.
Ref 536005FANCG is phosphorylated at serines 383 and 387 during mitosis. Mol Cell Biol. 2004 Oct;24(19):8576-85.
Ref 536059Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist. J Pharmacol Exp Ther. 2005 Jun;313(3):1263-71. Epub 2005 Mar 10.

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