Drug Information

Drug General Information
Drug ID
D0E6QI
Former ID
DIB008406
Drug Name
MEN-14295
Synonyms
MEN-14295; MEN-14536; MEN-15658; Rebeccamycin analogs, Menarini; Topoisomerase inhibitors (cancer); Topoisomerase inhibitors (cancer), Menarini
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543672]
Company
The Menarini Group
Structure
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2D MOL

3D MOL
Canonical SMILES
n1(c(=O)c2c(c1=O)c1c(n([C@H]3[C@@H]([C@@H](O[C@@H]4[C@@<br />H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)[C@@H]([C@H](O3)CO)O)<br />O)c3c1ccc(c3)O)c1c2c2c([nH]1)cc(cc2)O)NC(CO)CO
Target and Pathway
Target(s) Toposisomerase-1 Target Info Inhibitor [543672]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 543672(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636).
Ref 543672(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636).

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