Drug General Information
Drug ID	D0E8IZ
Former ID	DIB003284
Drug Name	Tonabersat
Synonyms	SB-220453; USL-260; 5-HT1d agonist (migraine), Minster; 5-HT1d agonist (migraine), SB
Drug Type	Small molecular drug
Indication	Epilepsy [ICD10:G40]		Phase 2	[522123]
Company	Upsher-smith laboratories
Structure		Download 2D MOL 3D MOL
Formula	C20H19ClFNO4
Canonical SMILES	[C@@H]1(c2c(OC([C@H]1O)(C)C)ccc(c2)C(=O)C)NC(=O)c1cc(c(<br />cc1)F)Cl
CAS Number	CAS 175013-84-0
PubChem Compound ID	6918324
Target and Pathway
Target(s)	5-hydroxytryptamine 1D receptor	Target Info	Agonist	[525903], [551730]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522123	ClinicalTrials.gov (NCT00534560) Dose Ranging Study of the Efficacy and Tolerability of Tonabersat in the Prophylaxis of Migraine Headache. U.S. National Institutes of Health.
Ref 525903	The potential anti-migraine compound SB-220453 does not contract human isolated blood vessels or myocardium; a comparison with sumatriptan. Cephalalgia. 2000 Jul;20(6):538-45.
Ref 551730	Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75.

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