Drug Information

Drug General Information
Drug ID
D0E8KS
Former ID
DNC001279
Drug Name
SB 203186
Drug Type
Small molecular drug
Indication Discovery agent Terminated [539648], [545117]
Structure
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2D MOL

3D MOL
Formula
C16H20N2O2
InChI
InChI=1S/C16H20N2O2/c19-16(20-11-10-18-8-4-1-5-9-18)14-12-17-15-7-3-2-6-13(14)15/h2-3,6-7,12,17H,1,4-5,8-11H2
InChIKey
YGKPIROTKVQCCU-UHFFFAOYSA-N
CAS Number
CAS 135938-17-9
PubChem Compound ID
3272300
PubChem Substance ID
4310608, 9251882, 11111770, 11113704, 15221946, 26751893, 34646190, 48018901, 48169370, 48393930, 50104570, 57356138, 77935497, 85213147, 85787316, 111881535, 123084781, 124749640, 124881385, 124881386, 124881387, 129792181, 134340485, 135650982, 136351878, 137031077, 138956298, 225044358, 227291137
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Antagonist [535385]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539648(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 255).
Ref 545117Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002177)
Ref 5353855-Hydroxytryptamine mediated contractions in isolated preparations of equine ileum and pelvic flexure: pharmacological characterization of a new 5-HT(4) agonist. J Vet Pharmacol Ther. 2002 Feb;25(1):49-58.

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