TTD | Drug: D0E8SE

Drug General Information
Drug ID	D0E8SE
Former ID	DIB013025
Drug Name	443C81
Synonyms	BW 443C; BW-443C81
Indication	Asthma [ICD10:J45]		Terminated	[544585]
Company	Burroughs Wellcome Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	N1(C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](Cc2ccc(<br />cc2)O)N)CCCNC(=N)N)Cc2ccc([N+](=O)[O-])cc2)[C@H](C(=O)N<br />)CCC1
Target and Pathway
Target(s)	Mu-type opioid receptor	Target Info	Modulator	[526731]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Estrogen signaling pathway
	Morphine addiction
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Enkephalin release
Pathway Interaction Database	IL4-mediated signaling events
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (i) signalling events
WikiPathways	TCR Signaling Pathway
	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	Opioid Signalling
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544585	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000227)
Ref 526731	Inhibition of cholinergic neurotransmission in human airways by opioids. J Appl Physiol (1985). 1992 Mar;72(3):1096-100.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Drug Information