Drug General Information
Drug ID	D0E8ZY
Former ID	DIB007692
Drug Name	Vapitadine
Synonyms	Hivenyl; Vapitadine dihydrochloride; R-129160; Vapitadine (oral), Barrier Therapeutics
Drug Type	Small molecular drug
Indication	Allergic skin disorders [ICD10:L00-L99]		Phase 2	[547977]
Company	Barrier Therapeutics Inc
Structure		Download 2D MOL 3D MOL
Formula	C17H20N4O
Canonical SMILES	c12n(c(cn1)C(=O)N)CCc1c(C32CCNCC3)cccc1
PubChem Compound ID	9842252
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Antagonist	[547978]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 547977	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020866)
Ref 547978	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020866)

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