Drug General Information
Drug ID	D0E9BF
Former ID	DIB011740
Drug Name	5-hydroxymethyl-2-furfural (sickle cell disease), AesRx LLC
Synonyms	Aes-103; 5-HMF; 5-hydroxymethylfurfural
Indication	Anemia [ICD9: 280-285; ICD10:D50-D64]		Phase 2	[524529]
Company	Aesrx
Structure		Download 2D MOL 3D MOL
Canonical SMILES	o1c(ccc1CO)C=O
Target and Pathway
Target(s)	Hemoglobin	Target Info	Modulator	[527406]
KEGG Pathway	African trypanosomiasis
	Malaria
Reactome	Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Scavenging of heme from plasma
WikiPathways	Binding and Uptake of Ligands by Scavenger Receptors
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
	Factors involved in megakaryocyte development and platelet production
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
References
Ref 524529	ClinicalTrials.gov (NCT01987908) Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease. U.S. National Institutes of Health.
Ref 527406	5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells. Br J Haematol. 2005 Feb;128(4):552-61.

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