Drug General Information
Drug ID	D0EH2O
Former ID	DIB013117
Drug Name	BIMG80
Indication	Psychotic disorders [ICD9: 290-299; ICD10:F20-F29]		Terminated	[546146]
Company	Boehringer Ingelheim Corp
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c2c([nH]c1)ccc(c2)OC)CC1=CCCN(C1)CCCC(=O)c1ccc(cc1)F
CAS Number	CAS 160418-78-0
Target and Pathway
Target(s)	Dopamine D1 receptor	Target Info	Modulator	[534408]
	D(4) dopamine receptor	Target Info	Modulator	[534408]
	D(2) dopamine receptor	Target Info	Modulator	[534408]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Morphine addiction
	Alcoholismhsa04080:Neuroactive ligand-receptor interaction
	Dopaminergic synapsehsa04015:Rap1 signaling pathway
	Alcoholism
PANTHER Pathway	Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Nicotine pharmacodynamics pathway
PathWhiz Pathway	Dopamine Activation of Neurological Reward System
Reactome	Dopamine receptors
	G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
	GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
References
Ref 546146	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006596)
Ref 534408	BIMG 80, a novel potential antipsychotic drug: evidence for multireceptor actions and preferential release of dopamine in prefrontal cortex. J Neurochem. 1997 Jul;69(1):182-90.

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