Drug General Information
Drug ID
D0EJ9B
Former ID
DNC005114
Drug Name
Phenyl Boronic acid
Synonyms
Phenylboronic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530358]
Structure
Download
2D MOL

3D MOL

Formula
C6H7BO2
Canonical SMILES
B(C1=CC=CC=C1)(O)O
InChI
1S/C6H7BO2/c8-7(9)6-4-2-1-3-5-6/h1-5,8-9H
InChIKey
HXITXNWTGFUOAU-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) D-alanyl-D-alanine carboxypeptidase Target Info Inhibitor [530358]
Carbonic anhydrase II Target Info Inhibitor [527231]
Carbonic anhydrase IV Target Info Inhibitor [529905]
Carbonic anhydrase Target Info Inhibitor [528141]
Fatty-acid amide hydrolase Target Info Inhibitor [529790]
Carbonic anhydrase I Target Info Inhibitor [527231]
BioCyc Pathway Anandamide degradation
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretionhsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamationhsa04723:Retrograde endocannabinoid signalinghsa00910:Nitrogen metabolism
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Anandamide degradation
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Gastric Acid Production
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 530358J Med Chem. 2009 Oct 8;52(19):6097-106.Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.
Ref 527231Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.
Ref 528141Bioorg Med Chem Lett. 2006 Jun 15;16(12):3139-43. Epub 2006 Apr 18.Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions.
Ref 529790J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
Ref 529905Bioorg Med Chem Lett. 2009 Feb 15;19(4):1155-8. Epub 2008 Dec 25.Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.
Ref 530358J Med Chem. 2009 Oct 8;52(19):6097-106.Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.

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