Drug Information

Drug General Information
Drug ID
D0EW6H
Former ID
DIB020245
Drug Name
LTC4
Synonyms
leukotriene C4
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540311]
Structure
Download
2D MOL
Formula
C30H47N3O9S
InChI
InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1
InChIKey
GWNVDXQDILPJIG-NXOLIXFESA-N
PubChem Compound ID
5280493
PubChem Substance ID
5241, 4266071, 7978470, 8144736, 8616294, 26756768, 39289599, 47439963, 50111412, 53787291, 57357762, 76781864, 92126168, 103591345, 113853360, 126523876, 127302679, 127302680, 127302681, 127302682, 127302683, 127302684, 127302685, 135651512, 137005676, 137240026, 138355248, 179293089, 184584916, 198947983, 237822003, 250135036, 252455506, 252467942
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Agonist [525529]
GPR17 Target Info Agonist [528446]
Leukotriene CysLT2 receptor Target Info Agonist [525921]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling PathwayNetPath_16:IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelinsendothelinpathway:Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 540311(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3354).
Ref 525529Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature. 1999 Jun 24;399(6738):789-93.
Ref 525921Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol Pharmacol. 2000 Dec;58(6):1601-8.
Ref 528446The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J. 2006 Oct 4;25(19):4615-27. Epub 2006 Sep 21.

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