Drug General Information
Drug ID
D0EX3I
Former ID
DNC003324
Drug Name
3,4-Methylenedioxymethamphetamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467812]
Structure
Download
2D MOL

3D MOL

Formula
C11H15NO2
InChI
InChI=1S/C11H15NO2/c1-8(12-2)5-9-3-4-10-11(6-9)14-7-13-10/h3-4,6,8,12H,5,7H2,1-2H3
InChIKey
SHXWCVYOXRDMCX-UHFFFAOYSA-N
CAS Number
CAS 42542-10-9
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Agonist [551382]
Synaptic vesicle amine transporter Target Info Antagonist [551382]
Sodium-dependent noradrenaline transporter Target Info Modulator [551382]
Sodium-dependent dopamine transporter Target Info Modulator [551382]
5-hydroxytryptamine 2A receptor Target Info Agonist [551382]
5-hydroxytryptamine 2B receptor Target Info Agonist [551382]
Sodium-dependent serotonin transporter Target Info Modulator [551382]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04721:Synaptic vesicle cycle
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholismhsa04728:Dopaminergic synapse
Alcoholismhsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channelshsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
CCKR signaling map STP00001:Adrenaline and noradrenaline biosynthesisP00001:Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-181430:Norepinephrine Neurotransmitter Release Cycle
Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transportersR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP2855:Dopaminergic Neurogenesis
Synaptic Vesicle Pathway
Neurotransmitter Release Cycle
Nicotine Activity on Dopaminergic NeuronsWP727:Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic CleftWP733:Serotonin Receptor 2 and STAT3 Signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
GPCR downstream signalingWP727:Monoamine Transport
Serotonin Transporter Activity
References
Ref 467812(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4574).
Ref 551382The origin of <span class="caps">MDMA</span> (ecstasy) revisited: the true story reconstructed from the original documents. Addiction. 2006 Sep;101(9):1241-5.

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