Drug Information

Drug General Information
Drug ID
D0F0YZ
Former ID
DAP000671
Drug Name
Pentobarbital
Synonyms
Aethaminalum; Dorsital; Etaminal; Ethaminal; Mebubarbital; Mebumal; Nebralin; Nembutal; Neodorm; Pentabarbital; Pentabarbitone; Pentobarbitale; Pentobarbitalum; Pentobarbitone; Pentobarbiturate; Rivadorm; Pentobarbital calcium; Pentobarbital suppository dosage form; Pentobarbitale [DCIT]; Pentobarbituric acid; Ethyl-propylmethylcarbinylbarbituric acid; Nembutal (TN); Nembutal (VAN); Neodorm (VAN); Neodorm (new); Pentobarbital (VAN); Pentobarbital [USP:INN]; Pentobarbital, Monosodium Salt; Pentobarbitalum [INN-Latin]; Pentobarbitone (VAN); Pentobarbital (USP/INN); (+-)-5-Ethyl-5-(1-methylbutyl)barbituric acid; 5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Ethyl-5-(1-methylbutyl)barbituric acid; 5-Ethyl-5-(1-methylbutyl)malonylurea; 5-Ethyl-5-(sec-pentyl)barbituric acid; 5-ethyl-2-hydroxy-5-(1-methylbutyl)pyrimidine-4,6(1H,5H)-dione; 5-ethyl-5-(pentan-2-yl)pyrimidine-2,4,6(1H,3H,5H)-trione;5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione
Drug Type
Small molecular drug
Indication Insomnia; Anxiety disorder [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52, 300, 311; ICD10:F51.0, G47.0, F32, F40-F42] Approved [538348], [540880], [551871]
Therapeutic Class
Hypnotics and Sedatives
Company
Oak Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL
Formula
C11H18N2O3
InChI
InChI=1S/C11H18N2O3/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
InChIKey
WEXRUCMBJFQVBZ-UHFFFAOYSA-N
CAS Number
CAS 76-74-4
PubChem Compound ID
4737
PubChem Substance ID
9626, 88629, 4875675, 7687719, 7847565, 8150116, 8152908, 10535336, 11336167, 11361406, 11364680, 11367242, 11369804, 11372904, 11374147, 11377967, 11462378, 11485937, 11489807, 11491598, 11492389, 11495597, 11533361, 15196098, 26612988, 26679656, 26750091, 29223823, 46508399, 47291210, 47440355, 47813402, 47885494, 48187638, 48416394, 49874341, 50107805, 53788844, 56313777, 57322422, 79087870, 92308182, 99302080, 103165831, 103858250, 103952389, 104307283, 104826284, 117425382, 124637312
ChEBI ID
ChEBI:7983
SuperDrug ATC ID
N05CA01
SuperDrug CAS ID
cas=000076744
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Antagonist [536555], [537688]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 538348FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 083270.
Ref 540880(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5480).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536555DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29.
Ref 537688Effect of barbiturates on polyphosphoinositide biosynthesis and protein kinase C activity in synaptosomes. Neuropharmacology. 1989 Dec;28(12):1317-23.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.