Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0F3JT
|
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| Former ID |
DAP000287
|
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| Drug Name |
Mecasermin
|
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| Synonyms |
Increlex (TN)
|
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| Therapeutic Class |
Immunomodulatory Agents
|
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| Formula |
C331H518N94O101S7
|
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| CAS Number |
CAS 68562-41-4
|
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| SuperDrug ATC ID |
H01AC03
|
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| Target and Pathway | |||||
| Target(s) | Insulin-like growth factor I receptor | Target Info | Inhibitor | [535735], [535760], [535800], [536311] | |
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| FoxO signaling pathway | |||||
| Oocyte meiosis | |||||
| Endocytosis | |||||
| PI3K-Akt signaling pathway | |||||
| AMPK signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Signaling pathways regulating pluripotency of stem cells | |||||
| Long-term depression | |||||
| Ovarian steroidogenesis | |||||
| Progesterone-mediated oocyte maturation | |||||
| Pathways in cancer | |||||
| Transcriptional misregulation in cancer | |||||
| Proteoglycans in cancer | |||||
| Glioma | |||||
| Prostate cancer | |||||
| Melanoma | |||||
| References | |||||
| Ref 535735 | One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist. Arthritis Rheum. 2003 May;48(5):1302-14. | ||||
| Ref 535760 | IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer. Virchows Arch. 2003 Aug;443(2):139-45. Epub 2003 Jul 5. | ||||
| Ref 535800 | Insulin-like growth factor I receptor gene structure. J Biol Chem. 1992 May 25;267(15):10759-63. | ||||
| Ref 536311 | Analysis of the human type I insulin-like growth factor receptor promoter region. Biochem Biophys Res Commun. 1991 Jun 28;177(3):1113-20. | ||||
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