Drug Information

Drug General Information
Drug ID
D0F3ZT
Former ID
DNC001155
Drug Name
Prucalopride
Drug Type
Small molecular drug
Indication Discovery agent Phase 4 [524070], [539559]
Structure
Download
2D MOL

3D MOL
Formula
C18H26ClN3O3
InChI
InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
InChIKey
ZPMNHBXQOOVQJL-UHFFFAOYSA-N
CAS Number
CAS 179474-81-8
PubChem Compound ID
3052762
PubChem Substance ID
10056110, 14803834, 36118680, 50329889, 57353981, 85209596, 96025885, 103341576, 104015490, 111619007, 124772073, 126522466, 126666797, 126731460, 129936276, 134340386, 135131495, 135650861, 135697691, 136367812, 137009981, 142510835, 143497674, 152090515, 152159696, 152234885, 162009741, 162011596, 162205091, 164764612, 170466188, 170502890, 174006285, 174528011, 175438062, 179150084, 185997006, 188899543, 196408592, 198942073, 198993142, 210275056, 210280694, 223379010, 223662148, 226407081, 249734221, 251883665, 251971243, 252151346
SuperDrug ATC ID
A06AX05
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Agonist [535146]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 524070ClinicalTrials.gov (NCT01692132) A Post Marketing Surveillance Study on the Safety and Effectiveness of Prucalopride in the Treatment of Chronic Constipation. U.S. National Institutes of Health.
Ref 539559(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 243).
Ref 535146Irritable bowel syndrome: new agents targeting serotonin receptor subtypes. Drugs. 2001;61(3):317-32.

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