Drug General Information
Drug ID	D0F4JK
Former ID	DIB011432
Drug Name	CE-224535
Synonyms	CP-23575
Drug Type	Small molecular drug
Indication	Arthralgia [ICD10:M25.5]		Phase 2/3	[522242]
Company	Pfizer Inc
Structure		Download 2D MOL 3D MOL
Formula	C22H29ClN4O6
Canonical SMILES	C1CCCCC(C1)(O)CNC(=O)c1c(ccc(c1)n1ncc(=O)n(c1=O)C[C@H](<br />COC)O)Cl
PubChem Compound ID	11547499
Target and Pathway
Target(s)	P2X purinoceptor 7	Target Info	Antagonist	[531823]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
Reactome	The NLRP3 inflammasome
WikiPathways	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
References
Ref 522242	ClinicalTrials.gov (NCT00628095) Study of CE-224,535 A Twice Daily Pill To Control Rheumatoid Arthritis In Patients Who Have Not Totally Improved With Methotrexate. U.S. National Institutes of Health.
Ref 531823	Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate. J Rheumatol. 2012 Apr;39(4):720-7.

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