Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0F5IY
|
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| Former ID |
DIB012079
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| Drug Name |
LIRIMILAST
|
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| Synonyms |
Lirimilast < Prop INN >; Methanesulfonic acid 2-(2,4-dichlorophenylcarbonyl)-3-ureidobenzofuran-6-ylester
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| Drug Type |
Small molecular drug
|
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| Indication | Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] | Phase 2 | [551720] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C17H12Cl2N2O6S
|
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| Canonical SMILES |
CS(=O)(=O)Oc1ccc2c(NC(=O)N)c(oc2c1)C(=O)c3ccc(Cl)cc3Cl
|
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| InChI |
1S/C17H12Cl2N2O6S/c1-28(24,25)27-9-3-5-11-13(7-9)26-16(14(11)21-17(20)23)15(22)10-4-2-8(18)6-12(10)19/h2-7H,1H3,(H3,20,21,23)
|
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| InChIKey |
YPFLFUJKZDAXRA-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | CAMP-specific 3',5'-cyclic phosphodiesterase 4B | Target Info | Inhibitor | [531635] | |
| Type IV phosphodiesterase | Target Info | Inhibitor | [551871] | ||
| CAMP-specific 3',5'-cyclic phosphodiesterase 4A | Target Info | Inhibitor | [544060] | ||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| IL2 Signaling Pathway | |||||
| PathWhiz Pathway | Purine Metabolism | ||||
| References | |||||
| Ref 531635 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. | ||||
| Ref 544060 | Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?. Br J Pharmacol. 2008 October; 155(3): 288-290. | ||||
| Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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