Drug Information

Drug General Information
Drug ID
D0F6CD
Former ID
DNC003553
Drug Name
SEROTONIN
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468120]
Structure
Download
2D MOL

3D MOL
Formula
C10H12N2O
InChI
InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
InChIKey
QZAYGJVTTNCVMB-UHFFFAOYSA-N
PubChem Compound ID
5202
PubChem Substance ID
4041, 803912, 3249485, 6492753, 7978601, 8144285, 8153195, 11111288, 11111289, 11120330, 11120818, 11121306, 11121741, 11122221, 11362866, 11364882, 11365428, 11367444, 11367990, 11370006, 11370943, 11370944, 11373045, 11373591, 11375606, 11376152, 11378175, 11466509, 11467629, 11485998, 15120541, 26737386, 26754231, 26754232, 26754233, 29224259, 47662064, 47662065, 47662066, 47662067, 47662068, 47810539, 47810540, 47885201, 47885202, 47885203, 47959524, 48110239, 48259014, 48334252
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Inhibitor [529789]
5-hydroxytryptamine 2C receptor Target Info Inhibitor [528498]
5-hydroxytryptamine 4 receptor Target Info Inhibitor [528498]
5-hydroxytryptamine 5A receptor Target Info Inhibitor [529569]
5-hydroxytryptamine 1D receptor Target Info Inhibitor [529496]
5-hydroxytryptamine 6 receptor Target Info Inhibitor [530739]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [530451]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [530451]
5-hydroxytryptamine receptor 3A Target Info Inhibitor [525484]
5-hydroxytryptamine 2B receptor Target Info Inhibitor [527833]
Adenosine A3 receptor Target Info Inhibitor [527823]
5-hydroxy-tryptamine 3B receptor Target Info Inhibitor [525484]
5-hydroxytryptamine 7 receptor Target Info Inhibitor [529569]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Serotonergic synapsehsa04024:cAMP signaling pathway
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
Serotonergic synapsehsa04726:Serotonergic synapsehsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channelshsa04726:Serotonergic synapsehsa04014:Ras signaling pathway
Calcium signaling pathway
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04375:5HT3 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04375:5HT3 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and SerotoninPW000444:Excitatory Neural Signalling Through 5-HTR 6 and SerotoninPW000443:Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling eventsR-HSA-975298:Ligand-gated ion channel transportR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-417973:Adenosine P1 receptors
G alpha (s) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
Iron uptake and transportWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
GPCR downstream signalingWP80:Nucleotide GPCRs
GPCRs, OtherWP2670:Iron uptake and transportWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCRs, Other
References
Ref 468120(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5).
Ref 525484J Med Chem. 1999 May 6;42(9):1556-75.Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.
Ref 527823J Med Chem. 2005 Nov 3;48(22):6887-96.2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Ref 527833Bioorg Med Chem Lett. 2006 Feb;16(3):677-80. Epub 2005 Oct 27.Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists.
Ref 528498J Nat Prod. 2006 Oct;69(10):1421-4.Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands.
Ref 529496J Med Chem. 2008 Jun 26;51(12):3609-16. Epub 2008 May 29.Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide.
Ref 529569J Med Chem. 2008 Jul 24;51(14):4150-69. Epub 2008 Jun 28.Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
Ref 529789J Med Chem. 2008 Nov 27;51(22):7094-8.cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Ref 530451J Med Chem. 2009 Nov 12;52(21):6946-50.Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.
Ref 530739J Med Chem. 2010 Mar 25;53(6):2521-7.5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.