Drug Information

Drug General Information
Drug ID
D0F6TD
Former ID
DNC001394
Drug Name
SUN N4057
Drug Type
Small molecular drug
Indication Coronary artery disease [ICD9: 410-414, 429.2; ICD10:I20-I25] Phase 2 [521780]
Structure
Download
2D MOL

3D MOL
Formula
C23H24ClN3O2
Canonical SMILES
C1CN(CC=C1C2=CC=CC=N2)CCCCN3C(=COC4=CC=CC=C4C3=O)Cl
InChI
1S/C23H24ClN3O2/c24-22-17-29-21-9-2-1-7-19(21)23(28)27(22)14-6-5-13-26-15-10-18(11-16-26)20-8-3-4-12-25-20/h1-4,7-10,12,17H,5-6,11,13-16H2
InChIKey
URMTUEWUIGOJBW-UHFFFAOYSA-N
CAS Number
CAS 182415-09-4
PubChem Compound ID
9801640
PubChem Substance ID
14757611, 24110439, 44837641, 77664488, 85210203, 103404244, 103994674, 129410258, 134221902, 135253309, 137249465, 142324708, 162223281, 198966192, 226869908
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [535277]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 521780ClinicalTrials.gov (NCT00272909) Efficacy of SUN N4057 in Subjects With Acute Ischemic Stroke and Measurable Penumbra on Magnetic Resonance Imaging (MRI). U.S. National Institutes of Health.
Ref 535277Experimental study of pharmacological hypothermia: enhanced neuroprotective effect of a novel 5-HT 1 A agonist SUN N4057 by the pharmacological hypothermia. No To Shinkei. 2001 Sep;53(9):853-8.

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