Drug Information

Drug General Information
Drug ID
D0F6WV
Former ID
DCL000917
Drug Name
PD-157695
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Preclinical [536463]
Company
Pfizer
Structure
Download
2D MOL

3D MOL
Formula
C13H10BrN3O4
Canonical SMILES
C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br
InChI
1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
InChIKey
MQBZVUNNWUIPMK-UHFFFAOYSA-N
PubChem Compound ID
3854666
PubChem Substance ID
5591039, 7980570, 9993997, 14852033, 26759489, 41934772, 48110581, 49684195, 50112982, 50221429, 53788115, 53800548, 57356606, 85209285, 85787141, 97803300, 99431513, 103547644, 104082381, 106118934, 112404235, 121380087, 125333764, 125433058, 128631686, 134339365, 134340331, 134340490, 134340502, 134964511, 135293912, 135650994, 135698246, 139121540, 162023547, 163124986, 163687365, 167450927, 187071964, 196399953, 204360502, 208264769, 223427138, 223777318, 227354209, 252156740, 252457432, 252473340
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Antagonist [536463]
D(3) dopamine receptor Target Info Antagonist [536463]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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