Drug Information

Drug General Information
Drug ID
D0F7TV
Former ID
DIB005451
Drug Name
Torbafylline
Synonyms
Torbaphylline; HWA-448
Drug Type
Small molecular drug
Indication Peripheral vascular disease [ICD9: 443.9; ICD10:I73.9] Terminated [532864]
Company
Hoechst Marion Roussel Inc
Structure
Download
2D MOL

3D MOL
Formula
C16H26N4O4
Canonical SMILES
c12c(c(=O)n(c(=O)n1C)CCCCC(O)(C)C)n(cn2)COCC
CAS Number
CAS 105102-21-4
PubChem Compound ID
65888
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [532864]
Type IV phosphodiesterase Target Info Modulator [532864]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Modulator [532864]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
TSH signaling pathwayWP35:G Protein Signaling Pathways
Nuclear Receptors Meta-Pathway
Opioid Signalling
References
Ref 532864Phosphodiesterase (PDE) inhibitor torbafylline (HWA 448) attenuates burn-induced rat skeletal muscle proteolysis through the PDE4/cAMP/EPAC/PI3K/Akt pathway. Mol Cell Endocrinol. 2014 Aug 5;393(1-2):152-63.
Ref 532864Phosphodiesterase (PDE) inhibitor torbafylline (HWA 448) attenuates burn-induced rat skeletal muscle proteolysis through the PDE4/cAMP/EPAC/PI3K/Akt pathway. Mol Cell Endocrinol. 2014 Aug 5;393(1-2):152-63.

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