Drug Information

Drug General Information
Drug ID
D0F8TG
Former ID
DIB019862
Drug Name
fluperlapine
Synonyms
C10967
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539835]
Structure
Download
2D MOL
Formula
C19H20FN3
InChI
InChI=1S/C19H20FN3/c1-22-8-10-23(11-9-22)19-17-5-3-2-4-14(17)12-15-6-7-16(20)13-18(15)21-19/h2-7,13H,8-12H2,1H3
InChIKey
OBWGMKKHCLHVIE-UHFFFAOYSA-N
PubChem Compound ID
49381
PubChem Substance ID
13150, 6609373, 7979279, 8181097, 12013044, 16827998, 26719743, 26754614, 29216069, 34714146, 46386904, 47212922, 47359854, 47657071, 48105148, 49681763, 50065048, 51161839, 57313198, 85209079, 85787799, 92308651, 92309148, 103259587, 103972301, 104357644, 118047217, 124659076, 124892258, 126418611, 128786630, 134222176, 135009043, 135650274, 137213959, 144205333, 162022405, 162221781, 163134726, 164824850, 170466413, 172080466, 176484515, 179150902, 184596034, 198943533, 223439752, 226509411, 241118261, 250081671
Target and Pathway
Target(s) 5-hydroxytryptamine 7 receptor Target Info Antagonist [533798]
5-hydroxytryptamine 6 receptor Target Info Antagonist [533798]
KEGG Pathway Ras signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 7 and SerotoninPW000444:Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
References
Ref 539835(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 279).
Ref 533798Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994 Mar;268(3):1403-10.

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