Drug Information

Drug General Information
Drug ID
D0F8ZI
Former ID
DNC005760
Drug Name
3-Morpholin-4-ylmethyl-5H-phenanthridin-6-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527682]
Structure
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2D MOL

3D MOL
Formula
C18H18N2O2
Canonical SMILES
C1COCCN1CC2=CC3=C(C=C2)C4=CC=CC=C4C(=O)N3
InChI
1S/C18H18N2O2/c21-18-16-4-2-1-3-14(16)15-6-5-13(11-17(15)19-18)12-20-7-9-22-10-8-20/h1-6,11H,7-10,12H2,(H,19,21)
InChIKey
YRZWAGRTCFCAAG-UHFFFAOYSA-N
PubChem Compound ID
44403357
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [527682]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 527682Bioorg Med Chem Lett. 2005 Oct 1;15(19):4221-5.4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors.
Ref 527682Bioorg Med Chem Lett. 2005 Oct 1;15(19):4221-5.4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors.

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