Drug General Information
Drug ID	D0FF3D
Former ID	DNC000929
Drug Name	Metazamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[537753]
Structure		Download 2D MOL 3D MOL
Formula	C11H12N2O2
Canonical SMILES	CC1=CNC(=O)N1C2=CC=C(C=C2)OC
InChI	1S/C11H12N2O2/c1-8-7-12-11(14)13(8)9-3-5-10(15-2)6-4-9/h3-7H,1-2H3,(H,12,14)
InChIKey	NHUPEUMBGMETKD-UHFFFAOYSA-N
CAS Number	CAS 347396-82-1
PubChem Compound ID	26433
PubChem Substance ID	8169168, 15389803, 29293278, 52942804, 57310251, 104297282, 126412022, 134989467, 160676502, 179323034, 198962743, 212547270, 226552593
Target and Pathway
Target(s)	Glucose-6-phosphate dehydrogenase	Target Info	Inhibitor	[537753]
BioCyc Pathway	Pentose phosphate pathway
	Pentose phosphate pathway (oxidative branch)
KEGG Pathway	Pentose phosphate pathway
	Glutathione metabolism
	Metabolic pathways
	Biosynthesis of antibiotics
	Carbon metabolism
	Central carbon metabolism in cancer
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway	Pentose Phosphate Pathway
	Warburg Effect
Reactome	TP53 Regulates Metabolic Genes
WikiPathways	Sulfation Biotransformation Reaction
	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Vitamin D Receptor Pathway
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	Cori Cycle
	Metabolism of carbohydrates
	Pentose Phosphate Pathway
	Glutathione metabolism
References
Ref 537753	Glucose utilization and activity of glucose-6-phosphate dehydrogenase, isocitrate dehydrogenase and malate dehydrogenase in rat erythrocytes after treatment with tuberculostatic agents. Vopr Med Khim. 1986 Sep-Oct;32(5):32-5.
Ref 537753	Glucose utilization and activity of glucose-6-phosphate dehydrogenase, isocitrate dehydrogenase and malate dehydrogenase in rat erythrocytes after treatment with tuberculostatic agents. Vopr Med Khim. 1986 Sep-Oct;32(5):32-5.

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