Drug Information

Drug General Information
Drug ID
D0FH7B
Former ID
DIB018783
Drug Name
AH 11110
Synonyms
AH11110; AH-11110
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543151]
Structure
Download
2D MOL
Formula
C21H27ClN2O2
InChI
InChI=1S/C21H26N2O2.ClH/c22-21(23-13-7-2-8-14-23)15-18(24)16-25-20-12-6-5-11-19(20)17-9-3-1-4-10-17;/h1,3-6,9-12,18,22,24H,2,7-8,13-16H2;1H
InChIKey
WWHGFIXWBLHHQB-UHFFFAOYSA-N
PubChem Compound ID
9907616
PubChem Substance ID
14877619, 24188740, 24890774, 45979279, 76648207, 135698426, 162248295, 163125745, 204380643, 241182044, 241377559, 249617234, 252166671
Target and Pathway
Target(s) Alpha-1B adrenergic receptor Target Info Antagonist [534189]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
AMPK Signaling
References
Ref 543151(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8461).
Ref 534189Structure activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D-subtype. J Pharmacol Exp Ther. 1996 Jul;278(1):136-44.

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