Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0G0BJ
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| Former ID |
DIB008231
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| Drug Name |
VE-821
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| Synonyms |
ATR serine/threonine protein kinase inhibitors (cancer), Oxford University; ATR serine/threonine protein kinase inhibitors (cancer), Vertex Pharmaceuticals
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| Drug Type |
Small molecular drug
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Investigative | [542940] | ||
| Company |
University of Oxford
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| Structure |
|
Download2D MOL |
|||
| Formula |
C18H16N4O3S
|
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| InChI |
InChI=1S/C18H16N4O3S/c1-26(24,25)14-9-7-12(8-10-14)15-11-20-17(19)16(22-15)18(23)21-13-5-3-2-4-6-13/h2-11H,1H3,(H2,19,20)(H,21,23)
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| InChIKey |
DUIHHZKTCSNTGM-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Serine threonine protein kinase ATR | Target Info | Inhibitor | [532880], [532980] | |
| PANTHER Pathway | p53 pathway | ||||
| p53 pathway feedback loops 2 | |||||
| Pathway Interaction Database | Fanconi anemia pathway | ||||
| ATR signaling pathway | |||||
| Signaling events mediated by TCPTP | |||||
| Circadian rhythm pathway | |||||
| BARD1 signaling events | |||||
| p53 pathway | |||||
| Reactome | Meiotic synapsis | ||||
| Activation of ATR in response to replication stress | |||||
| Regulation of HSF1-mediated heat shock response | |||||
| HDR through Single Strand Annealing (SSA) | |||||
| Processing of DNA double-strand break ends | |||||
| Presynaptic phase of homologous DNA pairing and strand exchange | |||||
| G2/M DNA damage checkpoint | |||||
| References | |||||
| Ref 532880 | Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970. Oncotarget. 2014 Jul 30;5(14):5674-85. | ||||
| Ref 532980 | ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Res. 2014 Dec 1;74(23):6968-79. | ||||
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