Drug Information

Drug General Information
Drug ID
D0G0VV
Former ID
DNCL002112
Drug Name
Bafetinib
Drug Type
Small molecular drug
Indication Bone disease; Chronic lymphocytic leukaemia; Metastatic hormone refractory prostate cancer [ICD9: 185; ICD10:M00-M99, C91, C61] Phase 2 [523198], [542828]
Company
CytRx
Structure
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2D MOL

3D MOL
Formula
C30H31F3N8O
InChI
InChI=1S/C30H31F3N8O/c1-19-4-7-23(13-27(19)39-29-36-10-8-26(38-29)22-14-34-18-35-15-22)37-28(42)20-5-6-21(25(12-20)30(31,32)33)16-41-11-9-24(17-41)40(2)3/h4-8,10,12-15,18,24H,9,11,16-17H2,1-3H3,(H,37,42)(H,36,38,39)/t24-/m0/s1
InChIKey
ZGBAJMQHJDFTQJ-DEOSSOPVSA-N
PubChem Compound ID
11387605
PubChem Substance ID
16481656, 23539877, 24770036, 42466793, 50086918, 77698388, 103482046, 104063920, 126679896, 136340257, 137150513, 140810745, 141894470, 163312234, 164043536, 164836111, 172914862, 174531022, 180190671, 198990636, 223683336, 228773215, 244669216, 249565589, 249582875, 252160748, 252214950, 252543450
Target and Pathway
Target(s) Lyn tyrosine kinase Target Info Modulator [1572591]
Proto-oncogene c-Abl Target Info Modulator [1572591]
KEGG Pathway Chemokine signaling pathway
NF-kappa B signaling pathway
Platelet activation
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Long-term depression
Epithelial cell signaling in Helicobacter pylori infection
Epstein-Barr virus infection
Viral carcinogenesishsa04012:ErbB signaling pathway
Ras signaling pathway
Cell cycle
Axon guidance
Neurotrophin signaling pathway
Pathogenic Escherichia coli infection
Shigellosis
Pathways in cancer
MicroRNAs in cancer
Chronic myeloid leukemia
Viral myocarditis
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway B cell activation
Parkinson disease
CCKR signaling map STP00008:Axon guidance mediated by Slit/Robo
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
BCR signaling pathway
LPA receptor mediated events
GMCSF-mediated signaling events
Glypican 1 network
Signaling events mediated by PTP1B
Regulation of p38-alpha and p38-beta
Thromboxane A2 receptor signaling
CXCR4-mediated signaling events
IL5-mediated signaling events
Class I PI3K signaling events
amb2 Integrin signaling
EPHA forward signaling
PDGFR-beta signaling pathway
IL8- and CXCR2-mediated signaling events
Signaling events mediated by Stem cell factor receptor (c-Kit)
EPO signaling pathway
IL8- and CXCR1-mediated signaling events
Ephrin B reverse signaling
Alpha-synuclein signalingp73pathway:p73 transcription factor network
ATM pathway
Regulation of Telomerase
Posttranslational regulation of adherens junction stability and dissassembly
Lissencephaly gene (LIS1) in neuronal migration and development
Neurotrophic factor-mediated Trk receptor signaling
Validated transcriptional targets of TAp63 isoforms
p53 pathway
Regulation of retinoblastoma protein
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Reactome GPVI-mediated activation cascade
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Fc epsilon receptor (FCERI) signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Dectin-2 family
CD209 (DC-SIGN) signaling
Platelet Adhesion to exposed collagen
Regulation of signaling by CBL
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-2029482:Regulation of actin dynamics for phagocytic cup formation
CDO in myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Factors involved in megakaryocyte development and platelet production
WikiPathways Kit receptor signaling pathway
IL-3 Signaling Pathway
Fc epsilon receptor (FCERI) signaling
Signaling by the B Cell Receptor (BCR)
Signaling by SCF-KIT
Growth hormone receptor signaling
B Cell Receptor Signaling Pathway
TSLP Signaling Pathway
RANKL/RANK Signaling Pathway
Platelet Adhesion to exposed collagen
GPVI-mediated activation cascade
Costimulation by the CD28 family
Cell surface interactions at the vascular wall
IL-5 Signaling PathwayWP2864:Apoptosis-related network due to altered Notch3 in ovarian cancer
Fcgamma receptor (FCGR) dependent phagocytosis
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Integrated Pancreatic Cancer Pathway
Pathogenic Escherichia coli infection
Regulation of Microtubule Cytoskeleton
Integrated Breast Cancer Pathway
Signaling by Robo receptor
Myogenesis
Factors involved in megakaryocyte development and platelet production
References
Ref 523198ClinicalTrials.gov (NCT01215799) Study of Bafetinib (INNO-406) as Treatment for Patients With Hormone-Refractory Prostate Cancer. U.S. National Institutes of Health.
Ref 542828(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7906).
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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