Drug Information

Drug General Information
Drug ID
D0G1YQ
Former ID
DIB016249
Drug Name
PDE4 inhibitors
Synonyms
PDE4 inhibitors (inflammatory diseases); PDE4 inhibitors (inflammatory diseases), Scottish Biomedical; Pseudothiohydantoin derivatives (inflammatory diseases), Scottish Biomedical; Rhodanine derivatives (inflammatory diseases), Scottich Biomedical
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Investigative [552020]
Company
Scottish Biomedical Ltd
Structure
Download
2D MOL

3D MOL
Canonical SMILES
C1CC(CC1)Oc1c(ccc(c1)/C=C/1\C(=O)NC(=N)S1)OC
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [543404]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [543405]
Type IV phosphodiesterase Target Info Inhibitor [543406]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid SignallingWP35:G Protein Signaling Pathways
TSH signaling pathway
References
Ref 552020The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma. Respir Res. 2004 May 5;5:4.
Ref 543404(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1300).
Ref 543405(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1301).
Ref 543406(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1303).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.