Drug Information

Drug General Information
Drug ID
D0G2LT
Former ID
DPR000095
Drug Name
RGH-1756
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Terminated [536463]
Company
Gedeon Richter
Structure
Download
2D MOL

3D MOL
Formula
C15H18N3O3+
Canonical SMILES
COC1=CC=C(C=C1)C2=N[N+](=C(C=C2)N)CCCC(=O)O
InChI
1S/C15H17N3O3/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20/h4-9,16H,2-3,10H2,1H3,(H,19,20)/p+1
InChIKey
ACVGNKYJVGNLIL-UHFFFAOYSA-O
CAS Number
CAS 207277-37-0
PubChem Compound ID
5275
PubChem Substance ID
5616197, 11111758, 11112886, 29224330, 47276724, 47810998, 48035368, 48259475, 49699088, 50111255, 56209868, 78050350, 85788574, 90341420, 99381439, 103286694, 103915235, 104308768, 124750275, 124881361, 124881362, 126408108, 134339538, 135858775, 162977892, 179149510
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Antagonist [536463]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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