Drug General Information
Drug ID
D0G2VC
Former ID
DNC011191
Drug Name
KT-5720
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540323]
Structure
Download
2D MOL

3D MOL

Formula
C32H31N3O5
InChI
InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32-/m0/s1
InChIKey
ZHEHVZXPFVXKEY-IKZDWWSZSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) MAP kinase p38 Target Info Inhibitor [525872]
Protein kinase C, alpha type Target Info Inhibitor [525872]
Mitogen-activated protein kinase 14 Target Info Inhibitor [525872]
Mitogen-activated protein kinase 11 Target Info Inhibitor [525872]
Mitogen-activated protein kinase 8 Target Info Inhibitor [525872]
Rho-associated protein kinase 1 Target Info Inhibitor [525872]
Ribosomal protein S6 kinase Target Info Inhibitor [525872]
Mitogen-activated protein kinase 1 Target Info Inhibitor [525872]
KEGG Pathway MAPK signaling pathway
Rap1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Oocyte meiosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Amyotrophic lateral sclerosis (ALS)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Influenza A
Epstein-Barr virus infection
Proteoglycans in cancerhsa04010:MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
Wnt signaling pathway
Focal adhesion
Tight junction
Gap junction
Natural killer cell mediated cytotoxicity
Fc gamma R-mediated phagocytosis
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Long-term depression
Insulin secretion
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
Pathogenic Escherichia coli infection
African trypanosomiasis
Amoebiasis
Hepatitis B
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
cAMP signaling pathway
Protein processing in endoplasmic reticulum
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
HTLV-I infection
Herpes simplex infection
Colorectal cancer
Pancreatic cancer
Choline metabolism in cancerhsa04022:cGMP-PKG signaling pathway
Chemokine signaling pathway
TGF-beta signaling pathway
Axon guidance
Regulation of actin cytoskeleton
MicroRNAs in cancerhsa04012:ErbB signaling pathway
AMPK signaling pathway
Acute myeloid leukemia
cGMP-PKG signaling pathway
Dorso-ventral axis formation
Adherens junction
B cell receptor signaling pathway
Estrogen signaling pathway
Alzheimer's disease
Prion diseases
Alcoholism
Viral carcinogenesis
Renal cell carcinoma
Endometrial cancer
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Central carbon metabolism in cancer
Choline metabolism in cancer
NetPath Pathway TCR Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
FSH Signaling Pathway
TCR Signaling PathwayNetPath_17:IL5 Signaling Pathway
TNFalpha Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
B cell activation
EGF receptor signaling pathway
FGF signaling pathway
Interferon-gamma signaling pathway
Oxidative stress response
Parkinson disease
TGF-beta signaling pathway
Ras Pathway
p53 pathway feedback loops 2
p38 MAPK pathwayP00002:Alpha adrenergic receptor signaling pathway
Angiogenesis
Apoptosis signaling pathway
Endothelin signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PDGF signaling pathway
VEGF signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
Toll receptor signaling pathway
p38 MAPK pathway
p38 MAPK pathwayP00003:Alzheimer disease-amyloid secretase pathway
FAS signaling pathway
Integrin signalling pathway
T cell activation
CCKR signaling map STP00016:Cytoskeletal regulation by Rho GTPase
Inflammation mediated by chemokine and cytokine signaling pathway
CCKR signaling map STP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
PI3 kinase pathway
p53 pathway by glucose deprivation
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Interleukin signaling pathway
CCKR signaling map ST
Pathway Interaction Database RhoA signaling pathway
Signaling mediated by p38-gamma and p38-deltaendothelinpathway:Endothelins
TCR signaling in na&#xef
Canonical NF-kappaB pathway
Signaling events regulated by Ret tyrosine kinase
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
mTOR signaling pathway
Ras signaling in the CD4+ TCR pathway
ErbB1 downstream signaling
Syndecan-4-mediated signaling events
ATF-2 transcription factor network
PDGFR-beta signaling pathway
Retinoic acid receptors-mediated signaling
IL8- and CXCR2-mediated signaling events
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2
PAR1-mediated thrombin signaling events
a6b1 and a6b4 Integrin signaling
IL8- and CXCR1-mediated signaling events
Regulation of Ras family activation
Downstream signaling in na&#xef
Endothelins
BCR signaling pathway
p73 transcription factor network
p38 MAPK signaling pathway
Atypical NF-kappaB pathway
IL4-mediated signaling events
CD40/CD40L signaling
IL12-mediated signaling events
Regulation of p38-alpha and p38-beta
CDC42 signaling events
Angiopoietin receptor Tie2-mediated signaling
FAS (CD95) signaling pathway
Glucocorticoid receptor regulatory network
IL2-mediated signaling events
Rapid glucocorticoid signaling
Regulation of Androgen receptor activity
IL6-mediated signaling events
p38 signaling mediated by MAPKAP kinases
CXCR3-mediated signaling events
Signaling mediated by p38-alpha and p38-beta
EPO signaling pathway
p53 pathway
S1P2 pathway
Trk receptor signaling mediated by the MAPK pathway
VEGFR3 signaling in lymphatic endothelium
FGF signaling pathway
RAC1 signaling pathway
Regulation of retinoblastoma proteinp73pathway:p73 transcription factor network
Plasma membrane estrogen receptor signaling
Regulation of retinoblastoma proteinfcer1pathway:Fc-epsilon receptor I signaling in mast cells
Endothelins
Noncanonical Wnt signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Osteopontin-mediated events
Reelin signaling pathway
TRAIL signaling pathway
IL1-mediated signaling events
FoxO family signaling
Ceramide signaling pathway
p75(NTR)-mediated signaling
ErbB2/ErbB3 signaling events
JNK signaling in the CD4+ TCR pathway
Nephrin/Neph1 signaling in the kidney podocyte
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Signaling events mediated by Stem cell factor receptor (c-Kit)
Syndecan-2-mediated signaling events
Ephrin B reverse signaling
N-cadherin signaling events
Signaling events mediated by focal adhesion kinase
Glypican 3 network
IL12 signaling mediated by STAT4prlsignalingeventspathway:Signaling events mediated by PRL
EPHB forward signaling
PAR4-mediated thrombin signaling events
amb2 Integrin signaling
Integrins in angiogenesis
EPHA forward signaling
Stabilization and expansion of the E-cadherin adherens junction
N-cadherin signaling eventsinsulin_pathway:Insulin Pathway
Regulation of Telomerase
IGF1 pathway
IL2 signaling events mediated by PI3K
RXR and RAR heterodimerization with other nuclear receptor
TGF-beta receptor signalingfcer1pathway:Fc-epsilon receptor I signaling in mast cells
Signaling events mediated by PRL
ErbB4 signaling events
GMCSF-mediated signaling events
S1P3 pathway
S1P4 pathway
Presenilin action in Notch and Wnt signaling
S1P1 pathway
Netrin-mediated signaling events
Arf6 downstream pathway
Class IB PI3K non-lipid kinase events
EGF receptor (ErbB1) signaling pathway
IFN-gamma pathway
BMP receptor signaling
ALK1 signaling events
Neurotrophic factor-mediated Trk receptor signaling
Syndecan-1-mediated signaling events
Nongenotropic Androgen signaling
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Cellular roles of Anthrax toxin
Alpha-synuclein signaling
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Activation of PKC through G protein coupled receptorPW000453:Fc Epsilon Receptor I Signaling in Mast CellsPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Fc Epsilon Receptor I Signaling in Mast CellsPW000659:Leucine Stimulation on Insulin SignalingPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Insulin Signalling
Reactome NOD1/2 Signaling Pathway
p38MAPK events
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
CDO in myogenesis
DSCAM interactions
VEGFA-VEGFR2 PathwayR-HSA-111933:Calmodulin induced events
Disinhibition of SNARE formation
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Inactivation, recovery and regulation of the phototransduction cascade
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+R-HSA-168638:NOD1/2 Signaling Pathway
ERK/MAPK targets
Oxidative Stress Induced Senescence
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-168638:NOD1/2 Signaling Pathway
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-193648:NRAGE signals death through JNK
NRIF signals cell death from the nucleus
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksR-HSA-111465:Apoptotic cleavage of cellular proteins
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
RHO GTPases Activate ROCKsR-HSA-166208:mTORC1-mediated signallingR-HSA-112409:RAF-independent MAPK1/3 activation
MAPK1 (ERK2) activation
Golgi Cisternae Pericentriolar Stack Reorganization
Regulation of actin dynamics for phagocytic cup formation
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Growth hormone receptor signaling
WikiPathways Toll-like receptor signaling pathway
Insulin Signaling
MAPK Cascade
MAPK Signaling Pathway
Nanoparticle-mediated activation of receptor signaling
Signal Transduction of S1P Receptor
Parkinsons Disease Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
NGF signalling via TRKA from the plasma membrane
Myogenesis
Integrin-mediated Cell Adhesion
DSCAM interactions
Regulation of toll-like receptor signaling pathwayWP673:ErbB Signaling Pathway
Calcium Regulation in the Cardiac Cell
EGF/EGFR Signaling Pathway
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
Wnt Signaling Pathway Netpath
G Protein Signaling Pathways
Kit receptor signaling pathway
Transcriptional activation by NRF2
Myometrial Relaxation and Contraction Pathways
Human Complement System
Cardiac Hypertrophic Response
Syndecan interactions
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Signaling by SCF-KIT
DAG and IP3 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
T-Cell Receptor and Co-stimulatory Signaling
Alpha 6 Beta 4 signaling pathway
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
Pathogenic Escherichia coli infection
Signaling Pathways in Glioblastoma
Endothelin Pathways
Regulation of Microtubule Cytoskeleton
FSH signaling pathway
miRs in Muscle Cell Differentiation
Opioid Signalling
Response to elevated platelet cytosolic Ca2+
Integration of energy metabolism
TOR SignalingWP75:Toll-like receptor signaling pathway
Monoamine Transport
Serotonin HTR1 Group and FOS Pathway
TCR Signaling Pathway
Senescence and Autophagy in Cancer
Interferon type I signaling pathways
Oxidative Stress
p38 MAPK Signaling Pathway
IL-4 Signaling Pathway
TGF beta Signaling Pathway
MAP kinase activation in TLR cascade
Structural Pathway of Interleukin 1 (IL-1)
JAK/STAT
Amyotrophic lateral sclerosis (ALS)
Cardiac Progenitor Differentiation
BDNF signaling pathway
B Cell Receptor Signaling Pathway
Prostate Cancer
TSLP Signaling Pathway
TWEAK Signaling Pathway
Leptin signaling pathway
RANKL/RANK Signaling Pathway
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
IL-1 signaling pathway
Signal amplification
Platelet homeostasis
MicroRNAs in cardiomyocyte hypertrophy
Angiogenesis
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
DNA Damage Response (only ATM dependent)
ErbB Signaling Pathway
FAS pathway and Stress induction of HSP regulation
Signaling of Hepatocyte Growth Factor Receptor
NLR Proteins
IL-3 Signaling Pathway
EBV LMP1 signaling
PDGF Pathway
Nanoparticle triggered regulated necrosis
TNF alpha Signaling Pathway
Signalling by NGF
Intrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
Type II diabetes mellitus
Regulation of toll-like receptor signaling pathway
Osteoclast SignalingWP524:G13 Signaling Pathway
Regulation of Actin Cytoskeleton
Focal Adhesion
Semaphorin interactions
GPCR downstream signaling
Apoptotic execution phase
Androgen receptor signaling pathwayWP673:ErbB Signaling Pathway
G13 Signaling Pathway
IL-2 Signaling Pathway
Cytoplasmic Ribosomal Proteins
IL-6 signaling pathway
Apoptosis-related network due to altered Notch3 in ovarian cancer
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Interleukin-11 Signaling Pathway
TSH signaling pathway
Signaling by Insulin receptor
TOR Signaling
AMPK Signaling
IL-5 Signaling PathwayWP75:Toll-like receptor signaling pathway
Serotonin Receptor 4/6/7 and NR3C Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Vitamin A and Carotenoid Metabolism
Hypothetical Network for Drug Addiction
EPO Receptor Signaling
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Bladder Cancer
Fc epsilon receptor (FCERI) signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
RAF/MAP kinase cascade
Genes and (Common) Pathways Underlying Drug Addiction
Nifedipine Activity
Aryl Hydrocarbon Receptor
IL-9 Signaling Pathway
IL17 signaling pathway
Alzheimers Disease
IL-7 Signaling Pathway
Integrated Breast Cancer Pathway
Thrombin signalling through proteinase activated receptors (PARs)
Signaling by FGFR
L1CAM interactions
Advanced glycosylation endproduct receptor signaling
Heart Development
Osteopontin Signaling
IL-5 Signaling Pathway
References
Ref 540323(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 337).
Ref 525872Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors.

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