Drug Information

Drug General Information
Drug ID
D0G3AR
Former ID
DIB004587
Drug Name
CX-717
Synonyms
CX-1763; CX-546; CX-614; CX-727; CX-729; CX-743; CX-815; S-40929; AMPAKINE compound (respiratory depression), BiovailLaboratories; AMPAKINE compound (respiratory depression), Valeant; First generation AMPA receptor modulators, Cortex/University of California; First-generation AMPAKINE compounds, University of California/Cortex
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Preclinical [542783], [547144]
Company
University of California
Structure
Download
2D MOL

3D MOL
Formula
C13H13NO4
InChI
InChI=1S/C13H13NO4/c15-13-8-6-10-11(17-5-4-16-10)7-9(8)18-12-2-1-3-14(12)13/h6-7,12H,1-5H2
InChIKey
RQEPVMAYUINZRE-UHFFFAOYSA-N
PubChem Compound ID
6451148
PubChem Substance ID
11972335, 14798527, 43042116, 57370278, 80251346, 99004853, 103722803, 123109526, 126729553, 135246548, 135374429, 137000037, 139458664, 144240095, 152053440, 160834641, 162221096, 163096646, 163401101, 164207460, 164836141, 172913315, 204384250, 223366172, 223379109, 223662915, 226972920, 247914918, 249864782, 250209617, 251897220, 252073141, 252158640, 252434304, 252514106
Target and Pathway
Target(s) Glutamate receptor AMPA subtype Target Info Modulator [531632]
References
Ref 542783(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7842).
Ref 547144Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013391)
Ref 531632Acute sleep deprivation: the effects of the AMPAKINE compound CX717 on human cognitive performance, alertness and recovery sleep. J Psychopharmacol. 2012 Aug;26(8):1047-57.

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