Drug General Information
Drug ID	D0G3MH
Former ID	DIB014392
Drug Name	PNU-96391A
Synonyms	DS 121; (-)-DS-121; (-)-OSU-6162
Drug Type	Small molecular drug
Indication	Substance dependence [ICD10:F10-F19]		Terminated	[532971]
Company	University of Gothenburg
Structure		Download 2D MOL 3D MOL
Formula	C15H23NO2S
Canonical SMILES	S(=O)(=O)(c1cc([C@H]2CN(CCC2)CCC)ccc1)C
CAS Number	CAS 150336-90-6
PubChem Compound ID	22283003
Target and Pathway
Target(s)	D(3) dopamine receptor	Target Info	Modulator	[532971]
	D(2) dopamine receptor	Target Info	Modulator	[532971]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Dopaminergic synapsehsa04015:Rap1 signaling pathway
	cAMP signaling pathway
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholism
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Dopamine receptors
	G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
	GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
	Genes and (Common) Pathways Underlying Drug Addiction
References
Ref 532971	The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects. Neuropsychopharmacology. 2015 Jan;40(2):472-9.
Ref 532971	The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects. Neuropsychopharmacology. 2015 Jan;40(2):472-9.

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