Drug Information

Drug General Information
Drug ID
D0G4RQ
Former ID
DCL000024
Drug Name
GSK 796406
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Discontinued in Phase 1 [549953]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C28H40N2O5
Canonical SMILES
CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C(=C2<br />)OC)OC)OC
InChI
1S/C28H40N2O5/c1-20(2)28(19-29,22-17-25(33-6)27(35-8)26(18-22)34-7)13-9-14-30(3)15-12-21-10-11-23(31-4)24(16-21)32-5/h10-11,16-18,20H,9,12-15H2,1-8H3
InChIKey
XQLWNAFCTODIRK-UHFFFAOYSA-N
PubChem Compound ID
1234
PubChem Substance ID
854012, 5588061, 7979354, 8151048, 10510120, 11120269, 11120757, 11121245, 11121448, 11121928, 11362517, 11365079, 11367641, 11370305, 11370306, 11373242, 11375803, 14834960, 24439579, 26752312, 26752313, 47440013, 47810532, 47885193, 47885194, 48110231, 48258991, 49878993, 50105237, 50105238, 57320831, 76626821, 85087629, 85286057, 85787221, 85788738, 90341545, 91721411, 92309799, 96024702, 99300713, 103235960, 103845994, 103925610, 104171189, 104297146, 117513596, 124749992, 124880746, 124880747
Target and Pathway
Target(s) Angiotensin-converting enzyme Target Info Inhibitor [549997]
Neutral endopeptidase Target Info Inhibitor [549997]
KEGG Pathway Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)hsa04614:Renin-angiotensin system
Hematopoietic cell lineage
Protein digestion and absorption
Alzheimer's disease
NetPath Pathway EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to AngiotensinsR-HSA-2022377:Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to AngiotensinsWP2729:Metabolism of Angiotensinogen to Angiotensins
Primary Focal Segmental Glomerulosclerosis FSGS
Alzheimers Disease
References
Ref 549953Mechanism of Vasopeptidase Inhibitor-Induced Plasma Extravasation: Comparison of Omapatrilat and the Novel Neutral Endopeptidase 24.11/Angiotensin-Converting Enzyme Inhibitor GW796406. JPET December 2005 vol. 315 no. 3 1306-1313.
Ref 549997Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406. J Pharmacol Exp Ther. 2005 Dec;315(3):1306-13.

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