Drug Information

Drug General Information
Drug ID
D0G5ZE
Former ID
DNC014759
Drug Name
MDL-28170
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Terminated [545554]
Structure
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2D MOL

3D MOL
Formula
C22H26N2O4
Canonical SMILES
CC(C)C(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2
InChI
1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20+/m0/s1
InChIKey
NGBKFLTYGSREKK-VQTJNVASSA-N
PubChem Compound ID
51435905
Target and Pathway
Target(s) Calpain Target Info Inhibitor [527555]
KEGG Pathway Protein processing in endoplasmic reticulum
Apoptosis
Alzheimer's disease
Reactome Degradation of the extracellular matrix
WikiPathways Focal Adhesion
Integrated Pancreatic Cancer Pathway
Alzheimers Disease
Integrin-mediated Cell Adhesion
References
Ref 545554Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003692)
Ref 527555Bioorg Med Chem Lett. 2005 Jun 15;15(12):3034-8.Synthesis of a small library of diketopiperazines as potential inhibitors of calpain.

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