Drug Information

Drug General Information
Drug ID
D0G7AZ
Former ID
DIB018284
Drug Name
[3H]enadoline
Synonyms
[3H]-enadoline; [3H]-CI977; [3H]CI977; [3H]CI-977
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540414]
Formula
C24H32N2O3
InChI
InChI=1S/C24H32N2O3/c1-25(23(27)16-18-6-4-7-22-19(18)9-15-28-22)20-8-11-24(10-5-14-29-24)17-21(20)26-12-2-3-13-26/h4,6-7,9,15,20-21H,2-3,5,8,10-14,16-17H2,1H3/t20-,21-,24-/m0/s1
InChIKey
JMBYBVLCYODBJQ-HFMPRLQTSA-N
PubChem Compound ID
60768
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Agonist [525997]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 540414(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3475).
Ref 525997Analysis of [3H]bremazocine binding in single and combinatorial opioid receptor knockout mice. Eur J Pharmacol. 2001 Mar 2;414(2-3):189-95.

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