Drug Information

Drug General Information
Drug ID
D0G7OZ
Former ID
DIB020743
Drug Name
pobilukast
Synonyms
SKF 104353
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540293]
Structure
Download
2D MOL
Formula
C26H34O5S
InChI
InChI=1S/C26H34O5S/c27-23(28)18-19-32-25(24(29)26(30)31)22-17-11-10-16-21(22)15-9-4-2-1-3-6-12-20-13-7-5-8-14-20/h5,7-8,10-11,13-14,16-17,24-25,29H,1-4,6,9,12,15,18-19H2,(H,27,28)(H,30,31)/t24-,25-/m1/s1
InChIKey
PZIFPMYXXCAOCC-JWQCQUIFSA-N
PubChem Compound ID
60842
PubChem Substance ID
7980602, 8187090, 12013889, 14931441, 43118180, 50064126, 57314143, 75080243, 96099815, 103188405, 103922128, 104321787, 117542091, 128990064, 135074316, 137106570, 178100365, 179149550, 198969838, 226496604
Target and Pathway
Target(s) Leukotriene CysLT2 receptor Target Info Antagonist [543686]
Cysteinyl leukotriene receptor 1 Target Info Antagonist [525572]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
IL3 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelinsendothelinpathway:Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 540293(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3334).
Ref 525572Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol Pharmacol. 1999 Sep;56(3):657-63.
Ref 543686(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 270).

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