Drug General Information
Drug ID	D0G7SP
Former ID	DIB005901
Drug Name	SB-209247
Synonyms	Ticolubant; LTB4 antagonist, SB
Drug Type	Small molecular drug
Indication	Psoriasis [ICD9: 696; ICD10:L40]		Terminated	[546167]
Company	SmithKline Beecham plc
Structure		Download 2D MOL 3D MOL
Formula	C23H19Cl2NO3S
Canonical SMILES	c1(SCc2nc(/C=C/C(=O)O)c(cc2)OCCc2ccccc2)c(Cl)cccc1Cl
CAS Number	CAS 154413-61-3
PubChem Compound ID	6441619
Target and Pathway
Target(s)	Leukotriene B4 receptor 1	Target Info	Antagonist	[527274]
KEGG Pathway	Neuroactive ligand-receptor interaction
NetPath Pathway	IL4 Signaling Pathway
Reactome	Leukotriene receptors
	G alpha (q) signalling events
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546167	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006734)
Ref 527274	Formation and protein binding of the acyl glucuronide of a leukotriene B4 antagonist (SB-209247): relation to species differences in hepatotoxicity. Drug Metab Dispos. 2005 Feb;33(2):271-81. Epub 2004 Nov 2.

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