Drug General Information
Drug ID
D0G8OD
Former ID
DNC005906
Drug Name
N-(benzyloxycarbonyl)-leucyl-glycine-nitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527885]
Structure
Download
2D MOL

3D MOL

Formula
C16H21N3O3
Canonical SMILES
CC(C)CC(C(=O)NCC#N)NC(=O)OCC1=CC=CC=C1
InChI
1S/C16H21N3O3/c1-12(2)10-14(15(20)18-9-8-17)19-16(21)22-11-13-6-4-3-5-7-13/h3-7,12,14H,9-11H2,1-2H3,(H,18,20)(H,19,21)/t14-/m0/s1
InChIKey
UFXQLUZNMRVTPU-AWEZNQCLSA-N
PubChem Compound ID
Target and Pathway
Target(s) Cathepsin L Target Info Inhibitor [527885]
Cathepsin S Target Info Inhibitor [527885]
Cathepsin K Target Info Inhibitor [527885]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritishsa04142:Lysosome
Tuberculosishsa04142:Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritis
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_22:Leptin Signaling Pathway
IL2 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway
MHC class II antigen presentationR-HSA-1442490:Collagen degradation
Activation of Matrix Metalloproteinases
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGSWP2796:Class I MHC mediated antigen processing & presentation
Trafficking and processing of endosomal TLRWP2018:RANKL/RANK Signaling Pathway
Osteoclast Signaling
References
Ref 527885J Med Chem. 2005 Dec 1;48(24):7688-707.Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.
Ref 527885J Med Chem. 2005 Dec 1;48(24):7688-707.Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.

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