Drug Information

Drug General Information
Drug ID
D0G9RW
Former ID
DIB003566
Drug Name
TAN-1496
Synonyms
TAN-1496A; TAN-1496B; TAN-1496C; TAN-1496D; TAN-1496E
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Terminated [545717]
Company
Takeda Pharmaceutical Co Ltd
Structure
Download
2D MOL
Canonical SMILES
[C@@]123N(C(=O)[C@@](N(C1=O)C)(SS3)CO)[C@H]1[C@]([C@@H]<br />([C@@]3(C(=O)C(C(O3)C)(C)C)C1)OC(=O)C)(C2)OC(=O)C
Target and Pathway
Target(s) Toposisomerase-1 Target Info Modulator [533845]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 545717Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004359)
Ref 533845TAN-1496 A, C and E, diketopiperazine antibiotics with inhibitory activity against mammalian DNA topoisomerase I. J Antibiot (Tokyo). 1994 Nov;47(11):1202-18.

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