Drug Information

Drug General Information
Drug ID
D0G9WE
Former ID
DIB018944
Drug Name
batrachotoxin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539690]
Structure
Download
2D MOL
Formula
C31H42N2O6
InChI
InChI=1S/C31H42N2O6/c1-18-16-32-19(2)25(18)26(35)38-20(3)22-8-9-30-23-7-6-21-14-29(36)11-10-27(21,4)31(23,39-29)24(34)15-28(22,30)17-33(5)12-13-37-30/h7-8,16,20-21,24,32,34,36H,6,9-15,17H2,1-5H3/t20-,21+,24+,27-,28-,29+,30-,31-/m0/s1
InChIKey
ISNYUQWBWALXEY-OMIQOYQYSA-N
PubChem Compound ID
6324647
PubChem Substance ID
7980186, 36756132, 42973615, 49874683, 79511334, 135652668, 137259822, 198951953
Target and Pathway
Target(s) SCN8A sodium channel subunit Target Info Activator [543883]
Sodium channel protein type 2 subunit alpha Target Info Activator [534744]
Voltage-gated sodium channel subunit alpha Nav1.3 Target Info Activator [543881]
mRNA of SCN1A Target Info Activator [543880]
Voltage-gated sodium channel subunit alpha Nav1.7 Target Info Activator [543884]
Voltage-gated sodium channel subunit alpha Nav1.8 Target Info Activator [527277]
Sodium channel protein type 4 subunit alpha Target Info Activator [534563]
Sodium channel protein type 5 subunit alpha Target Info Activator [532575]
KEGG Pathway Dopaminergic synapsehsa04261:Adrenergic signaling in cardiomyocytes
PathWhiz Pathway Muscle/Heart Contraction
Reactome Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and Ankyrins
WikiPathways SIDS Susceptibility Pathways
Cardiac Progenitor Differentiation
References
Ref 539690(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2619).
Ref 527277The poison Dart frog's batrachotoxin modulates Nav1.8. FEBS Lett. 2004 Nov 5;577(1-2):245-8.
Ref 532575Binding of [3H]batrachotoxinin A benzoate to specific sites on rat cardiac sodium channels. Mol Pharmacol. 1986 Dec;30(6):617-23.
Ref 534563Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2653-8.
Ref 534744Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13947-52.
Ref 543880(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 578).
Ref 543881(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 580).
Ref 543883(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 583).
Ref 543884(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 584).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.